Rat Blood–Brain Barrier Genomics. II

Blood-brain barrier genomics.

The blood-brain barrier (BBB) is formed by the brain microvascular endothelium, and the unique transport properties of the BBB are derived from tissue-specific gene expression within this cell. The current studies developed a gene microarray approach specific for the BBB by purifying the initial mRNA from isolated rat brain capillaries to generate tester cDNA. A polymerase chain reaction-based ...

Functional genomics and rat models.

The 20th Century has seen a remarkable number of inventions and technological advances in virtually all aspects of human life and health care. Many areas of biomedical research have made great strides in unraveling the cause of human disease and in developing new therapies to counter, or at least improve, outcome from disease. However, the cause of the vast majority of common disease remains po...

II. Therapy of DLBCL based on genomics.

The activated B-cell-like (ABC) and germinal centre B-cell-like (GCB) subtypes of diffuse large B-cell lymphoma (DLBCL) were defined by their apparent derivation from different stages of B-cell differentiation and their differential response to chemotherapy [1]. With current chemotherapy supplemented with Rituximab, the ABC DLBCL subtype remains less curable [2,3], necessitating new approaches ...

Comparative Genomics II: From Genomes to Evolution

This is the second lecture in a series of two lectures on the work being done in Prof. Kellis’s lab on comparative genomics. Comparing genomes of related species at different evolutionary distances can teach us both about the genetic code and about evolution. In this lecture we discussed two examples of what we can learn about evolution using comparative genomics. The topics of this lecture are...

Comparative Genomics II: From Genomes to Evolution